Evidence map›Paper›PMID 41419169›Full record

ArticleVirus research2026

Characterization of minigenome systems for Hantaan and Seoul hantaviruses.

Shilpi Jain, Punya Shrivastava-Ranjan, Joel M Montgomery, Christina F Spiropoulou, César G Albariño

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shilpi JainViral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: qgs7@cdc.gov.
Punya Shrivastava-RanjanViral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Joel M MontgomeryViral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Christina F SpiropoulouViral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
César G AlbariñoViral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: bwu4@cdc.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some rodent-borne hantaviruses are known to cause hemorrhagic fever with renal syndrome in Europe and Asia, and hantavirus cardiopulmonary syndrome in the Americas. Despite the significant public health threat caused by hantaviruses, there are no antiviral therapeutics approved to treat hantavirus infections. One of the major limitations to study these viruses is the requirement for biosafety level 3 (BSL-3) containment. To address this concern, we previously generated a Seoul virus (SEOV) minigenome system which could be used to screen antivirals at BSL-2 level. Here, we report the development of a similar minigenome system based on the L segment of the prototype hantavirus, Hantaan virus (HTNV). In addition, we examined the activity of minigenomes based on M and S segments of SEOV and HTNV. Furthermore, we used the new HTNV minigenome system to confirm the activity of a selected group of antiviral compounds targeting the viral polymerase. All tested compounds (2'-deoxy-2'-Fluorocytidine, baloxavir, remdesivir and ribavirin) show potent anti-HTNV activity. The minigenome systems could be useful tools to study replication mechanisms and to screen antiviral compounds against hantaviruses at lower containment laboratories.

Indexed as

Genome, ViralHantaan virusSeoul virusAnimalsAntiviral AgentsCell LineDrug Evaluation, PreclinicalHumansVirus ReplicationAntiviral AgentsAntiviralHantaan virusHantaviridaeMinigenomesOrthohantavirusSeoul virus

Identifiers

PMID41419169
PMCPMC12775967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.