Evidence map›Paper›PMID 41419055›Full record

Trial reportContemporary clinical trials2026

Remotely-delivered exercise training program among older adults with multiple sclerosis: Feasibility results of a randomized controlled trial.

Peixuan Zheng, Sydney R DeJonge, Noah G DuBose, Ariel Kidwell-Chandler, Trevor B Martin, Trinh L T Huynh, Shane A Phillips, Jennifer Duffecy, Robert W Motl

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peixuan ZhengDepartment of Kinesiology and Health, School of Arts School of Arts and Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA. Electronic address: peixuan.zheng@rutgers.edu.
Sydney R DeJongeDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Noah G DuBoseDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Ariel Kidwell-ChandlerDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Trevor B MartinDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Trinh L T HuynhDepartment of Medicine, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Shane A PhillipsDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Jennifer DuffecyDepartment of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Robert W MotlDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.

Funding

Pilot CoreP30AG022849 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Tanvi Bhatt, DAVID X MARQUEZ · 2003 to 2026
$14.7M
NIA NIH HHS P30 AG022849
6 · The paper itself

Abstract

backgroundOlder adults with multiple sclerosis (MS) are often physically inactive and present with walking and cognitive impairments that may be remediated through rehabilitation approaches such as exercise training.

objectivesWe conducted a phase-Ib, randomized controlled trial (RCT) that examined the feasibility and initial efficacy of a 16-week remotely-delivered, home-based exercise training program in older adults with MS who had moderate mobility disability.

methodsThis study utilized a parallel-group RCT design. Participants (n = 51; mean age = 60.5 years, 78 % females) were randomized into exercise training (aerobic and resistance) or active control (stretching) conditions. Both conditions were undertaken within a participant's home/community and remotely supported by a behavioral coach. Participants received training manuals and equipment, one-on-one behavioral coaching, action-planning calendars, self-monitoring logs, and social cognitive theory-based newsletters. Feasibility was assessed across process, resource, management, and scientific domains. Scientific outcomes focused on physical function, cognition, and physical activity, with data collected by treatment-blinded assessors.

resultsThe intervention was cost-effective, accessible, well-received, and safe based on formative evaluation. Forty-one (80.4 %) participants completed the conditions, with adherence and compliance rates across conditions exceeding 80 %. There were moderate-to-large improvements in walking speed, functional mobility, lower-extremity function, and verbal learning and memory (p < 0.05, |d| = 0.58-0.80) in the exercise condition, but not in control (p > 0.05).

conclusionsThis study established the feasibility and initial efficacy of a theory-based, remotely-delivered exercise training intervention for older adults with MS. The promising results support the design and implementation of a subsequent, phase-II RCT for improving physical and cognitive functions in the older MS population.

Indexed as

Exercise TherapyMultiple SclerosisAgedCognitionCognitive DysfunctionExerciseFeasibility StudiesFemaleHumansMaleMiddle AgedResistance TrainingAgingCognitionExercise interventionMultiple sclerosisRehabilitationWalking

Identifiers

PMID41419055
PMCPMC13325967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.