Evidence map›Paper›PMID 41419052›Full record

ArticleThe Journal of investigative dermatology2026

Single-cell and spatial transcriptomics implicate vascular cell orchestration of inflammatory changes after UV light exposure in skin.

Jie An, Rachael Bogle, Rayan Najjar, Lam C Tsoi, J Michelle Kahlenberg, Ksenia Anufrieva, Erin Theisen, Kevin Wei, Johann E Gudjonsson, Keith B Elkon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie AnDivision of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address: jiean@uw.edu.
Rachael BogleDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Rayan NajjarDivision of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
J Michelle KahlenbergDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Division of Rheumatology, Department of Internal Medicine, Ann Arbor, Michigan, USA.
Ksenia AnufrievaDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Erin TheisenDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kevin WeiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Division of Rheumatology, Department of Internal Medicine, Ann Arbor, Michigan, USA.
Keith B ElkonDivision of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6M
Pathogenic fibroblast differentiation in rheumatoid arthritisK08AR077037 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEI, KEVIN S · 2020 to 2024
$799k
cGAMP as an immunotransmitter of the interferon response to UV lightR21AR077842 · NIAMS · UNIVERSITY OF WASHINGTON · PI ELKON, KEITH B. · 2021 to 2021
$427k
NCI NIH HHS P30 CA015704NIAMS NIH HHS K08 AR077037NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R21 AR077842
6 · The paper itself

Abstract

To elucidate the complex effects of acute UVR on the skin, we exposed mouse skin to UVB and performed transcriptomic profiling of the epidermis, deep dermis, and adipose tissue. Spatial transcriptomic analysis revealed gene expression changes in the epidermis, dermis, and adipose. Whereas CD45

Indexed as

SkinUltraviolet RaysAdipose TissueAnimalsEndothelial CellsEpidermisGene Expression ProfilingHumansKeratinocytesMiceSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSpatial TranscriptomicsTranscriptomeInflammationSingle-cell RNA sequenceSpatial transcriptomicsUV light

Identifiers

PMID41419052
PMCPMC13004582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.