ArticleArchives of physical medicine and rehabilitation2026
Understanding and Assessing Health-Related Quality of Life in Caregivers of Individuals With Traumatic Brain Injury and Comorbid Posttraumatic Stress Disorder.
Article in Archives of physical medicine and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo establish the reliability and validity of measures from the Traumatic Brain Injury-Caregiver Quality of Life (TBI-CareQOL) measurement system in care partners of individuals with comorbid traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) and to compare health-related quality of life (HRQOL) between care partners of individuals with TBI with and without PTSD.
designSurvey study.
settingTwo academic medical centers.
participantsA total of 246 care partners of individuals with TBI.
interventionsNot applicable.
main outcome measuresPsychometric qualities of Quality of Life In Neurological Disorders (Neuro-QoL) TBI-CareQOL Caregiver Strain and Caregiver-Specific Anxiety, Patient-Reported Outcomes Measurement Information System (PROMIS) short form assessments of Anger, Anxiety, Depression, Fatigue, Ability to Participate in Social Roles and Activities, and Sleep-Related Impairment, National Institutes of Health Toolbox assessments of Perceived Stress and Self-Efficacy, Neuro-QoL Positive Affect and Well-Being.
resultsOur results provide evidence for the internal consistency reliability for all TBI-CareQOL measures (α≥0.70), which were also devoid of ceiling and floor effects, excluding a slightly elevated floor effect (23%) for PROMIS Depression. Convergent and discriminant validity were established by demonstrating moderate-to-high correlations between similar constructs, and minimal-to-low correlations between dissimilar constructs. Known groups validity was established by demonstrating significantly worse HRQOL for care partners of individuals with both TBI and PTSD compared with care partners for individuals with TBI alone. Caring for an individual with PTSD was associated with elevated impairment rates in comparison with the general population and care partners of individuals without PTSD. We also demonstrate significant negative correlations between measures of care partner HRQOL and posttraumatic stress disorder checklist for DSM-5 score, and provide evidence that PTSD significantly predicts Caregiver Strain above and beyond functional impairment in the care recipient and time spent caregiving.
conclusionsWe provide evidence for the clinical utility of TBI-CareQOL measures in care partners of individuals with both TBI and PTSD. Our data also suggest that caring for individuals with both PTSD and TBI is associated with lower HRQOL and higher impairment.
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