ArticleStem cell reports2026
RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation.
Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Protocol for manipulating mRNA splicing via vivo-morpholino in early-activating muscle stem cells.STAR protocols · 2026Article
- Mechanical Signaling Regulates DNA Methylation to Maintain Muscle Stem Cell Quiescence.bioRxiv : the preprint server for biology · 2026Article
- Splice choices at the threshold of activation: Alternative splicing fine-tunes Notch signaling in muscle stem cells.Stem cell reports · 2026Article
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Authors and funding
8 authors.
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Abstract
Satellite cells (SCs) are somatic stem cells essential for skeletal muscle regeneration. Most SCs remain quiescent in resting muscle, but they rapidly activate in response to stimuli. Although post-transcriptional regulation has been implicated in SC functions, the role of alternative splicing (AS) during SC activation remains unclear. Using in vivo fixation to preserve quiescent SCs, we uncovered rapid and extensive AS changes upon activation, affecting genes involved in fundamental pathways. We identified RBFOX2 as a key AS regulator in SCs; its loss delayed both SC activation and muscle regeneration. Particularly, RBFOX2 promotes the inclusion of exon 6 in Numb, a Notch pathway regulator. This exon is required for SC activation, and its skipping delays activation while upregulating Notch signaling. Altogether, our study provides the AS landscape during SC activation and demonstrates that a single-gene splicing change can significantly influence SC activation and essential pathways such as Notch signaling.
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