Trial reportMultiple sclerosis and related disorders2026
Feasibility and efficacy of peak-velocity interval training vs. moderate-intensity walking training in people with multiple sclerosis with severe fatigue and walking impairment: A pilot randomized controlled trial.
Trial report in Multiple sclerosis and related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06264336 (Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionHigh-intensity interval training (HIIT) may yield greater improvements in walking and fatigue for people with multiple sclerosis (MS) than moderate-intensity, continuous training (MICT). This pilot project established the feasibility of peak velocity interval walking training (PVIT, a novel form of HIIT) in people with MS who had elevated fatigue and walking dysfunction and determined initial efficacy on fitness, walking, fatigue, and cognition.
methodsTwelve people with MS [49.3 (7.4) years of age; 9 female; 1-34 years post diagnosis; Fatigue Severity Scale Score >4; Patient-Determined Disease Steps score 3-6] were randomly assigned into PVIT (n = 7) or MICT (n = 5) and completed 12 sessions of training up to 40 min. Feasibility was measured throughout as rates of recruitment, randomization, retention, adherence, and compliance. Pre- and post-assessments included peak oxygen consumption, walking performance, fatigue severity, and cognition.
resultsAll participants who enrolled were successfully randomized and completed all sessions (100 % retention) with no adverse events. Adherence was high (86 %) as was intensity compliance (100 %) and did not differ between groups. PVIT resulted in greater walking velocity (relative to maximal overground velocity, 95 % vs. 70 %) and heart rate reserve (93 % vs. 55 %) than MICT. Peak oxygen consumption improved more in the PVIT than MICT condition (14 % vs. 1 % improvement, p < 0.05).
conclusionInitial results suggest that PVIT as a form of HIIT is safe, feasible, and may improve aerobic fitness more than MICT in people with MS who have elevated fatigue and impaired walking function. CLINICAL
trial registrationClinicalTrials.gov: NCT06264336.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.