Evidence map›Paper›PMID 41418427›Full record

ArticleMolecular pharmacology2026

Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels.

Illia Gelman, Wentao Li, Jun Guo, Reese Bogart-Cherry, Nicole Tomei, Neelakshi Sharma, Angelia Pan, Tonghua Yang, Adrian Baranchuk, Mohammad El-Diasty and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Illia GelmanDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Wentao LiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Jun GuoDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Reese Bogart-CherryDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Nicole TomeiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Neelakshi SharmaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Angelia PanDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Tonghua YangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Adrian BaranchukDivision of Cardiology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Mohammad El-DiastyDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Division of Cardiac Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Shetuan ZhangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address: shetuan.zhang@queensu.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The class III antiarrhythmic drug amiodarone (AMIO) inhibits the rapidly activating delayed rectifier K

Indexed as

AmiodaroneAnti-Arrhythmia AgentsEther-A-Go-Go Potassium ChannelsAnimalsERG1 Potassium ChannelHEK293 CellsHumansMyocytes, CardiacPatch-Clamp TechniquesRatsAmiodaroneAnti-Arrhythmia AgentsdesethylamiodaroneERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsKCNH2 protein, humanAmiodaronehERGLong QT syndrome

Identifiers

PMID41418427
PMCPMC12881259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.