ReviewBiological chemistry2026
Mechanistic insights into Ras-catalyzed GTP hydrolysis: conformational dynamics, catalytic mechanisms, and emerging therapeutic strategies.
Review in Biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Fred Wittinghofer and the GTP/GDP-binding proteins.Biological chemistry · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ras is a key regulator of signal transduction in cells. Ras malfunction is associated with a huge variety of oncological diseases. It is turned off by hydrolysis of bound GTP, which is accelerated by GTPase-activating proteins (GAPs). This minireview discusses the mechanism of Ras-catalyzed GTP hydrolysis, focusing on conformational dynamics and catalytic mechanisms. We discuss structural changes and the role of key residues such as Thr35, Gly60, Tyr32, Gln61, Gly12, and Gly13. Biophysical techniques such as X-ray crystallography, time-resolved FTIR spectroscopy, and hybrid quantum mechanics/molecular mechanics calculations have revealed the detailed reaction mechanisms, including the entry of the arginine finger and the rate-limiting step of inorganic phosphate release. Recent studies on the hydrolysis mechanism favor a solvent-assisted pathway. In addition, we summarize recent advances in Ras-targeting drugs.
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41418323What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.