Evidence map›Paper›PMID 41418090›Full record

ReviewNeurology(R) neuroimmunology & neuroinflammation2026

Astrocyte Biology in CNS Inflammatory Diseases: A Clinical-Translational Perspective.

Jessica Ye, Francisco J Quintana

Abstract readReview
In one paragraph

Review in Neurology(R) neuroimmunology & neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jessica YeAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-8392-7423
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-8156-0736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes are the main structural cells of the brain and spinal cord. Tessellating throughout the entire tissue, these highly arborized cells form intimate connections with each other and with essentially all other cell types in the CNS, including neurons, other glia such as microglia and oligodendrocyte-lineage cells, blood vessel cells, pial epithelium, and peripheral immune cells, when present. However, far more than inert cells gluing the CNS together, astrocytes are diverse and dynamic. Through their connections, they adapt and respond to local tissue cues, influencing CNS homeostasis and pathology. Yet, astrocyte biology is only superficially appreciated in clinical spheres. In this article, we briefly review some of the major facets of astrocyte biology as relevant to various neuroinflammatory diseases, including multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated disorders, neuromyelitis optica spectrum disorders, anti-glial fibrillary acidic protein autoimmune encephalitis, and other neuroimmune conditions, highlighting their clinical and biological significance.

Indexed as

AstrocytesNeuroinflammatory DiseasesAnimalsAutoimmune Diseases of the Nervous SystemHumansMultiple Sclerosis

Identifiers

PMID41418090
PMCPMC12721598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.