Evidence map›Paper›PMID 41417926›Full record

ArticleScience immunology2025

Divergent immune responses to commensal bacteria bearing distinct motility signatures.

Lennard W Duck, Melissa S Jennings, Jung-Shan Hsu, Covenant F Adeboboye, E Leighann Morgan, Kiarra J Coger, Barbara J Klocke, Dave D Hill, Katie L Alexander, Alexander F Rosenberg and 4 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lennard W DuckDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-4746-4959
Melissa S JenningsDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jung-Shan HsuDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-3541-9296
Covenant F AdeboboyeDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
E Leighann MorganDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0009-0007-3117-0749
Kiarra J CogerDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9794-4021
Barbara J KlockeDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Dave D HillDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1337-1789
Katie L AlexanderDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-3862-2940
Alexander F RosenbergDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Goo LeeDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-3025-5234
Qing ZhaoDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-2862-3886
Charles O ElsonDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-8873-1534
Craig L MaynardDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5876-8168

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
INNATE AND ADAPTIVE MICROBIAL IMMUNITY IN IBDP01DK071176 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELSON, CHARLES O · 2005 to 2014
$12.5M
Immune Interactions with the Mucus-Associated MicrobiotaR01AI162736 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MAYNARD, CRAIG L · 2021 to 2025
$2.3M
T Cell Co-stimulation and the Resistance of Regulatory T cells to Gut InflammationR21DK118386 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MAYNARD, CRAIG L · 2019 to 2021
$557k
NCI NIH HHS P30 CA013148NIAID NIH HHS R01 AI162736NIAID NIH HHS T32 AI007051NIDDK NIH HHS P01 DK071176NIDDK NIH HHS R21 DK118386
6 · The paper itself

Abstract

Adaptive immune responses to commensal flagellins are hallmarks of Crohn's disease (CD), but it is unclear whether flagellins themselves promote inflammation or whether flagellated commensals can also be colitogenic. Here, we show that the arrangement of motility loci and the diversity of encoded flagellins can separate flagellated gut-derived

Indexed as

Crohn DiseaseFlagellinGastrointestinal MicrobiomeAnimalsGerm-Free LifeHumansMiceMice, Inbred C57BLSymbiosisToll-Like Receptor 5FlagellinToll-Like Receptor 5

Identifiers

PMID41417926
PMCPMC12875389

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.