ArticleScience advances2025
EGFR activation requires cholesterol interaction at the inner leaflet of the plasma membrane.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins.Scientific reports · 2026Article
- Niemann-Pick type C1 protein regulates epidermal growth factor receptor stability in hepatic cells and facilitates the early steps of Hepatitis B virus infection.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal transduction by the human epidermal growth factor receptor (EGFR) is modulated by its ligands as well as by the various compounds on the plasma membrane (PM), including cholesterol. Here, using single-molecule coimmunoimmobilization, we found that cholesterol in the inner leaflet of PM plays an essential role in ligand-dependent EGFR activation. This was done by direct and quantitative examination of the interaction between EGFR and cholesterol on the PM of a living cell. Structural analysis using molecular dynamics simulations and nuclear magnetic resonance spectroscopy further revealed that cholesterol in the inner leaflet is critically important for the transition of the dimeric transmembrane domain (TMD) of the receptor to the active conformation. We also identified the specific pattern of residues Ile
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