Evidence map›Paper›PMID 41417900›Full record

ArticleScience advances2025

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1.

Michael L Freeman, Brian M Clagett, Konstantin Leskov, Daniela Moisi, George A Yendewa, Scott F Sieg, Gregory M Laird, Jonathan Karn, Jeffrey M Jacobson, Benigno Rodriguez and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael L FreemanRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-7690-5258
Brian M ClagettDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.ORCID 0009-0006-4046-125X
Konstantin LeskovRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-6201-5660
Daniela MoisiDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
George A YendewaRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.
Scott F SiegRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-1769-8682
Gregory M LairdAccelevir Diagnostics, Baltimore, MD, USA.ORCID 0000-0003-2873-4295
Jonathan KarnRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-2900-094X
Jeffrey M JacobsonRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-0725-249X
Benigno RodriguezDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Michael M LedermanRustbelt Center for AIDS Research, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-9247-8025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eliciting HIV-1 expression from latently infected CD4

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsInterleukin-2Virus LatencyAdultCD4-Positive T-LymphocytesHumansKiller Cells, NaturalLymphocyte ActivationMaleMiddle AgedRecombinant ProteinsRNA, ViralViral LoadVirus ReplicationAnti-HIV AgentsInterleukin-2Recombinant ProteinsRNA, Viral

Identifiers

PMID41417900
PMCPMC12716389

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.