ArticleScience advances2025
Growth hormone is required for hippocampal engram cell maturation.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Comprehensive protein synthesis inhibition impairs natural and artificial memory recall.Molecular brain · 2026Article
- Protein synthesis blockade prevents fear memory reactivation via inhibition of engram synapse strengthening.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
Memory is stored in specialized cells known as engram cells, but the molecular mechanisms underlying this process remain unclear. We discovered that the initial translation leading to growth hormone (GH) synthesis in engram cells is required for their maturation in the mouse dentate gyrus. Time-course experiments with a translation inhibitor suggested that the key molecule is immediately translated during learning. We identified GH as the crucial factor, specifically translated within the first few minutes of consolidation in engram cells. Blocking GH activity with a dominant-negative (G118R) mutation blocked engram maturation, whereas facilitating activity-dependent GH uptake alleviated engram maturation deficits caused by translation inhibition. Together, our findings propose GH as a key mediator of hippocampal engram cell maturation.
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