Evidence map›Paper›PMID 41417887›Full record

ArticleScience advances2025

VNUT-mediated ATP release suppresses T helper 1 (T

Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bolong WuState Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, China.ORCID 0000-0003-1457-1720
Linlin ShengState Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, China.ORCID 0000-0001-5848-2290
Ziyi FengState Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, China.
Xiaohu WangInstitute for Immunology, School of Basic Medical Sciences, Tsinghua University, 100084 Beijing, China.ORCID 0000-0002-5073-0488
Ligong ChenState Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, China.ORCID 0000-0002-7893-7173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular ATP (eATP), a well-recognized danger signal and immune activator, is implicated in the activation, differentiation, and function of T cells, directly or indirectly. Yet, how T cells release ATP themselves and its effects remain poorly investigated. Here, we found vesicular nucleotide transporter (VNUT), critical for vesicular ATP storage/release, is highly expressed in T

Indexed as

Adenosine TriphosphateCell DifferentiationForkhead Box Protein O3Nucleotide Transport ProteinsReceptors, Purinergic P2X7Signal TransductionTh1 CellsAnimalsHumansMiceAdenosine TriphosphateForkhead Box Protein O3FoxO3 protein, mouseNucleotide Transport ProteinsReceptors, Purinergic P2X7

Identifiers

PMID41417887
PMCPMC13142776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.