ArticleRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2025
Association of triglycerides/high-density lipoprotein ratio with cardiometabolic risk factors in children from mothers who had gestational diabetes.
Article in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of the study was to evaluate the association between triglycerides/high-density lipoprotein-cholesterol (TG/HDL) ratio and cardiometabolic risk factors in children of mothers who had gestational diabetes (GDM).
methodsThis retrospective cohort study involved 227 offspring aged 2-14 years, born to mothers with GDM. Data was collected during routine antenatal care, and the offspring were evaluated 2-14 years later. TG/HDL ratio was stratified into tertiles. Cardiometabolic risk factors were defined according to the World Health Organization (WHO) criteria for children: obesity, overweight, elevated waist circumference, elevated blood pressure and hypertension, dysglycemia, low HDL-cholesterol, and elevated TG. The association of TG/HDL ratio and cardiometabolic risk factors was evaluated through comparative and linear regression analysis.
resultsThere were higher mean levels of some markers of cardiometabolic risk factors according to TG/HDL ratio tertiles. We observed higher frequencies of elevated HbA1c from 2 to 4 years (0 vs. 3.7 vs. 12.9%, p-linear-by-linear <0.001); higher prevalence of overweight/obesity from 5 to 9 years (39.1 vs. 47.2 vs. 75.0%, p-linear-by-linear<0.001), and higher frequencies of elevated low density lipoprotein-cholesterol from 10 to 14 years (33.3 vs. 66.6 vs. 77.7%, p-linear-by-linear=0.044) according to TG/HDL ratio tertiles. TG/HDL ratio was associated with homeostasis model assessment-insulin resistance from 5 to 9 years (β0.11 [95% confidence interval (95%CI) 0.00-0.23]) and from 10 to 14 years (β0.10 [95%CI 0.02-0.18]), after adjustments for sex and body mass index.
conclusionsOur results show that higher levels of TG/HDL ratio are associated with worse cardiometabolic profile and insulin resistance in offspring from mothers who had gestational diabetes mellitus and can be a good marker to identify those at higher cardiometabolic risk.
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