SynthesisRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2025
Gene variants associated with skin barrier dysfunction in atopic dermatitis: a systematic review and meta-analysis.
Synthesis in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
objectiveThe aim of this systematic review and meta-analysis was to identify genetic variants associated with skin barrier dysfunction and analyze their contribution to the development of atopic dermatitis (AD). DATA SOURCE: A comprehensive search of six databases (2002-2022) yielded 20 eligible casecontrol studies involving European and Asian populations. DATA SYNTHESIS: Meta-analyses revealed significant associations between AD and specific variants in the FLG, SPINK5, LAMA3, HRNR, and COL8A1 genes. Notably, FLG variants such as R501X, 3321delA, and rs61816761 showed high odds ratios (up to OR=11.22), particularly in Spanish and Korean populations. SPINK5 variants including A1103G and G1258A were also significantly associated, especially in Asian cohorts.
conclusionsVariants affecting skin barrier integrity are strongly linked to AD susceptibility. These findings confirm the role of genetic factors across diverse populations and support translational strategies such as genetic screening, early diagnosis, and personalized treatment in pediatric dermatology.
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