ArticleChemistry & biodiversity2026
Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots.Chemistry & biodiversity · 2026Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Pythiosis, caused by the oomycete Pythium insidiosum, is a worrying disease with its challenging treatment due to the phylogeny of the pathogen. Natural products are a promising alternative in the treatment of diseases. Cordia insignis (Boraginaceae) is a poorly studied species, but Cordia species exhibit broad bioactivity. This study investigated phytochemically the roots of the species and evaluated the anti-oomycete activity of the crude extract (CE) and fractions against P. insidiosum. Seven compounds were isolated and identified, including β-sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucopyranosyl, tridecanoic acid, scoparone, and gracicleistanthoside. The steroids, saponin and coumarin, were reported of leaves and branches of C. insignis; the fatty acid and glycoside are being first reported for the genus. The oomyceticidal assays revealed promising potential, with the hexane fraction (FH) being the most potent (minimum inhibitory concentration [MIC]/minimum oomicidal concentration [MOC] of 15.625 µg/mL). In conclusion, this study expands the chemotaxonomic knowledge of C. insignis and highlights the pharmacological potential of its roots against pythiosis.
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