ReviewJournal of medicinal chemistry2026
Validating Natural Compounds as Toll-Like Receptor 4 (TLR4) Antagonists: Experimental Challenges and Therapeutic Perspectives.
Review in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluation of toll-like receptor inhibition by novel thymoquinone analogues as potential remedy for diabetic nephropathy.Molecular diversity · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activation of TLR4 by endogenous damage or danger-associated molecular patterns (DAMPs) suggested the use of TLR4 antagonists to target acute and chronic inflammatory diseases. In recent years, hundreds of natural compounds (NCs) have been screened for their activity as TLR4 antagonists. However, the direct interaction with TLR4 or TLR4/MD-2 dimer has not been proven for most of the natural molecules, and their mechanism of action has been only partially investigated. We review the recent literature on NCs active as TLR4 antagonists, analyzing the limitations and selecting among all candidates the compounds presenting new scaffolds desirable for drug development. After selecting a collection of representative hit structures, we also present novel docking calculations on TLR4/MD-2. Our analysis allowed the detection of common binding motifs in the receptor and the proposal of a structure-activity relationship from the ligands, enabling the discovery of new ligand scaffolds and pharmacophores for further development of drug hits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.