Evidence map›Paper›PMID 41417356›Full record

ArticleMemorias do Instituto Oswaldo Cruz2025

Influence of a hyperglycaemic diet on Trypanosoma cruzi infection in mice model.

Aline Coelho das Mercês, Flávia de Souza Marques, Bruno Teixeira Martins, Gabriel José Lucas Moreira, Bruno Mendes Roatt, Cláudia Martins Carneiro, Silvia de Paula-Gomes, Joana Ferreira do Amaral, Paula Melo de Abreu Vieira

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Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Aline Coelho das MercêsUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Departamento de Ciências Biológicas, Laboratório de Morfopatologia, Ouro Preto, MG, Brasil.
Flávia de Souza MarquesUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Departamento de Ciências Biológicas, Laboratório de Morfopatologia, Ouro Preto, MG, Brasil.
Bruno Teixeira MartinsUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Departamento de Ciências Biológicas, Laboratório de Morfopatologia, Ouro Preto, MG, Brasil.
Gabriel José Lucas MoreiraUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Laboratório de Imunopatologia, Ouro Preto, MG, Brasil.
Bruno Mendes RoattUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Laboratório de Imunopatologia, Ouro Preto, MG, Brasil.
Cláudia Martins CarneiroUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Laboratório de Imunopatologia, Ouro Preto, MG, Brasil.
Silvia de Paula-GomesUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Laboratório de Bioquímica e Biologia Molecular, Ouro Preto, MG, Brasil.
Joana Ferreira do AmaralUniversidade Federal de Ouro Preto, Laboratório Multiusuário de Bioquímica Nutricional, Ouro Preto, MG, Brasil.
Paula Melo de Abreu VieiraUniversidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Núcleo de Pesquisas em Ciências Biológicas, Departamento de Ciências Biológicas, Laboratório de Morfopatologia, Ouro Preto, MG, Brasil.ORCID 0000-0001-7033-7686

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParasitic diseases may increase the risk of metabolic abnormalities through persistent inflammation. However, the effects of a hyperglycaemic diet during Trypanosoma cruzi infection remain poorly understood.

objectivesThis study aimed to investigate the metabolic, parasitological, immunological, and histological effects of a hyperglycaemic diet during acute T. cruzi infection in mice.

methodsC57BL/6 mice were divided into four groups: non-infected with standard diet (NISD), infected with a standard diet (ISD), non-infected with hyperglycaemic diet (NIHD), and infected with hyperglycaemic diet (IHD). Animals were fed their respective diets for eight weeks prior to infection and monitored up to 30 days post-infection (DPI) for blood glucose, body mass, biochemical markers, parasitaemia, tissue alterations, and immune cell profiles.

findingsAt the time of infection, hyperglycaemic diet groups showed higher blood glucose and body mass. By 30 DPI, these animals exhibited lower glucose, increased parasitaemia, adipose tissue hypertrophy, and reduced cholesterol levels compared with controls. Infected groups showed an increased CD4+ IFN-γ+ T cells at 10 DPI, whereas macrophage expansion was observed only in ISD mice. Cardiac parasitism was higher at 30 DPI than at 10 DPI. MAIN

conclusionsThese results show that T. cruzi infection affects metabolic parameters and that a hyperglycaemic diet worsens parasitological outcomes during the acute phase of infection and appears to downregulate the immune response.

Indexed as

Chagas DiseaseDietHyperglycemiaTrypanosoma cruziAnimalsBlood GlucoseDisease Models, AnimalMiceMice, Inbred C57BLParasitemiaBlood Glucose

Identifiers

PMID41417356
PMCPMC12711203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.