ArticleRevista da Sociedade Brasileira de Medicina Tropical2025
Presence of Viable Bacilli in Multibacillary Leprosy After 12 Doses of Multidrug Therapy.
Article in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundWe investigated the clinical profiles of patients with multibacillary leprosy treated with at least 12 doses of multidrug therapy (MDT), in whom intact Mycobacterium leprae bacilli were identified in skin biopsies.
methodsClinical and therapeutic characteristics of 30 patients were analyzed, and their association with bacillary integrity was assessed.
resultsLeprosy reactions were commonly observed. Two-thirds of patients completed treatment within 5 years. A strong association was observed between the 12-dose regimen and the presence of intact bacilli.
conclusionsClinical and laboratory aspects should be considered when deciding to discontinue MDT, particularly if leprosy reactions occur.
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