Trial reportClinical oral investigations2025
Effects of fixed orthodontic treatment on taste perception: a randomized controlled trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06989736 (Evaluation of Taste Sensation Changes in Individuals Undergoing Fixed Orthodontic Treatment), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Taste Sensation Changes in Individuals Undergoing Fixed Orthodontic Treatment
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate whether fixed orthodontic treatment leads to measurable changes in taste perception. The primary objective was to assess alterations in the perception of sweet, salty, sour, and bitter tastes before and after treatment initiation. MATERIALS AND
methodsA total of 128 patients aged 10-19 from the Orthodontics Clinic of Biruni University were randomly assigned to either a fixed orthodontic treatment group (n = 64) or a control group (n = 64). Taste perception was evaluated using nine solutions (two concentrations each of sweet, salty, sour, and bitter, plus a neutral control) administered before treatment and again six weeks later. Perceived taste intensity was measured using a Visual Analog Scale (VAS). Statistical comparisons were performed using the Mann-Whitney U test, Wilcoxon Signed-Rank test, and Pearson Chi-Square test.
resultsSignificant changes were observed within the experimental group: sweet taste scores (low concentration) decreased, and bitter taste scores (high concentration) increased from the first to the second session (p < 0.05). However, no significant differences were found between the experimental and control groups across all taste modalities and time points (p > 0.05).
conclusionsFixed orthodontic appliances may cause minor, short-term alterations in taste perception, specifically for sweet and bitter tastes. These changes are likely influenced by salivary flow and are not clinically significant when compared to untreated individuals. CLINICAL RELEVANCE: Clinicians should inform patients that mild and temporary changes in taste may occur during the initial phase of fixed orthodontic treatment. These effects are manageable and typically resolve with good oral hygiene and adaptation to the appliance.
trial registrationThis study was retrospectively registered at ClinicalTrials.gov (NCT06989736) on May 23, 2025.
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Registered trials
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