Evidence map›Paper›PMID 41417191›Full record

ArticleMolecular diversity2026

Synthesis of imidazo[2,1-a]isoquinolin-5-ones via C-H imidoylmethylation/oxidation/cyclization cascade of 2-arylbenzimidazoles with CF

Juting Liao, Ruirui Zhai, Yuming Zhang, Junyu Xu, Hongliang Wu, Guiwei Yao, Yuchao Luo, Dulin Kong, Shuojin Wang, Xun Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recent progress in the application of CFMolecular diversity · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juting LiaoEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Ruirui ZhaiEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Yuming ZhangSecond School of Clinical Medicine, Hainan Medical University, Haikou, 571199, China.
Junyu XuEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Hongliang WuEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Guiwei YaoEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Yuchao LuoEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Dulin KongEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China. kongdulin@muhn.edu.cn.
Shuojin WangEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China. wang.shuojin@muhn.edu.cn.
Xun ChenEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China. chenxun@muhn.edu.cn.

Funding

Hainan Provincial Natural Science Foundation of China 222RC683Hainan Provincial Natural Science Foundation of China 825QN329National Natural Science Foundation of China 21901054the Key R&D Projects of Hainan Province ZDYF2024SHFZ065
6 · The paper itself

Abstract

A direct C-H imidoylmethylation and subsequent oxidation/cyclization reaction of 2-arylbenzimidazoles with CF

Indexed as

BenzimidazolesCopperImidazolesIsoquinolinesRhodiumAntineoplastic AgentsCatalysisCell Line, TumorCyclizationHumansMethylationOxidation-ReductionSulfonium CompoundsAntineoplastic AgentsBenzimidazolesCopperImidazolesIsoquinolinesRhodiumSulfonium Compoundssulfoxonium2-ArylbenzimidazolesCF3-imidoyl sulfoxonium ylidesC–H imidoylmethylationImidazo[2,1-a]isoquinolin-5-onesOxidation/cyclization reaction

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.