Evidence map›Paper›PMID 41417149›Full record

ArticleBreast cancer (Tokyo, Japan)2026

Safety of radiotherapy in patients undergoing breast reconstruction based on patient-reported outcomes: a multicenter collaborative study.

Hirohito Seki, Noriyuki Watanabe, Naomi Nagura, Akiko Ogiya, Ayaka Shimo, Natsue Uehiro, Wakako Tsuji, Shoichi Tomita, Takahiro Tsukioki, Tomohiro Shiraishi and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hirohito SekiDepartment of Breast Surgery, Tokyo Medical Center, NHO, 2-5-1 Higashigaoka Meguroku, Tokyo, 152-8902, Japan. hirohito.seki@gmail.com.ORCID http://orcid.org/0000-0002-3211-4817
Noriyuki WatanabeDepartment of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.
Naomi NaguraDepartment of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Akiko OgiyaDepartment of Breast Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Ayaka ShimoDepartment of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Natsue UehiroDepartment of Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Wakako TsujiDepartment of Breast Surgery, Shiga General Hospital, Shiga, Japan.
Shoichi TomitaDepartment of Plastic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Takahiro TsukiokiDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Tomohiro ShiraishiDepartment of Plastic and Reconstructive Surgery, Kyorin University Hospital, Tokyo, Japan.
Yutaka NishidaCenter for Data Science Education and Research, Kyorin University, Tokyo, Japan.
Chikako YamauchiDepartment of Radiation Oncology, Shiga General Hospital, Shiga, Japan.
Shinsuke SasadaDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Collaborative Study Group of Scientific Research of the Japan Oncoplastic Breast Surgery Society

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-mastectomy radiation therapy (PMRT) improves oncological outcomes of high-risk patients with breast cancer. However, its impact on breast reconstruction remains unclear. This study aimed to evaluate the safety of PMRT in breast reconstruction from the patient's perspective.

methodsThis multicenter cross-sectional study was conducted in 10 Japanese institutions. Patient-reported outcomes (PROs) were collected using a comprehensive questionnaire incorporating surgical complications and the Japanese version 2.0 of the BREAST-Q "Adverse effect of radiation" module from 830 patients with breast cancer who had undergone reconstruction (214 with PMRT, 616 without). Complication rates were compared between the PMRT and non-PMRT groups. Logistic regression analysis was used to identify independent predictors of complications.

resultsThe PMRT group showed a significantly higher overall complication rate (76.2% vs. 45.3%, P < 0.001), including dermatitis (48.1% vs. 9.9%, P < 0.001), cutaneous necrosis (9.8% vs. 2.9%, P < 0.001), capsular contracture (16.4% vs. 4.9%, P = 0.020), breast asymmetry (24.3% vs. 17.0%, P = 0.020), and upper limb lymphedema (7.5% vs. 1.1%, P < 0.001) versus the non-PMRT group. In the multivariate analysis, PMRT was identified as an independent risk factor only for cutaneous necrosis (P < 0.001). Adverse effects of radiation were observed in the PMRT group, including dryness (52.3%), pigmentation (46.4%), irritation (39.8%), soreness (38.7%), telangiectasias (36.4%), and skin thickness changes (33.2%).

conclusionThis is the first large-scale investigation in Japan to evaluate PMRT-related complications in patients who underwent breast reconstruction using PROs. Although PMRT increases complication rates, its direct impact is limited. These findings highlight the importance of incorporating patient-centered data into shared decision-making regarding reconstruction strategies.

Indexed as

Breast NeoplasmsMammaplastyPatient Reported Outcome MeasuresPostoperative ComplicationsAdultAgedCross-Sectional StudiesFemaleHumansJapanMastectomyMiddle AgedRadiotherapy, AdjuvantSurveys and QuestionnairesBreast cancerBreast reconstructionPatient-reported outcomeRadiation therapySafety

Identifiers

PMID41417149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.