Evidence map›Paper›PMID 41417114›Full record

ReviewOrthopadie (Heidelberg, Germany)2026

[LLM-based extraction of clinical data: potentials and challenges].

Paulina Seidl, Marton Szep, Sebastian Breden, Fiona Charitou, Carolin Mogler, Peter Schüffler, Rüdiger von Eisenhart-Rothe, Igor Lazic, Florian Hinterwimmer

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Orthopadie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paulina SeidlKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland. paulina.seidl@tum.de.
Marton SzepKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Sebastian BredenKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Fiona CharitouKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Carolin MoglerInstitut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, München, Deutschland.
Peter SchüfflerInstitut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, München, Deutschland.
Rüdiger von Eisenhart-RotheKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Igor LazicKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Florian HinterwimmerKlinik und Poliklinik für Orthopädie und Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLarge language models (LLM) can automatically process clinical free-text documents, extract key information, and thereby reduce reading effort and documentation-related workload. High-quality data and targeted model control are essential for practical applicability. MATERIAL AND

methodsVarious approaches to information extraction are presented. Additionally, 24 unstructured pathological reports of bone and soft tissue tumors are processed using the local, generic LLM Llama 4 Scout with three different prompt variants and compared in terms of extraction quality.

resultsPrompt design had a substantial impact on model behavior. Prompts with clear parameter definitions and examples achieved the most reliable results. Typical LLM-specific errors, such as hallucinations and misclassifications, were also observed. LLM can support clinical staff by rapidly and systematically extracting relevant content from free-text documents. Safe and effective use requires high-quality data, precise inputs, and close collaboration between medical and technical experts.

Indexed as

Data MiningInformation Storage and RetrievalNatural Language ProcessingBone NeoplasmsHumansArtificial intelligenceDocumentationElectronic health recordsMedical informaticsNatural language processing

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.