Evidence map›Paper›PMID 41417101›Full record

Trial reportClinical oral investigations2025

Effect of sodium hypochlorite and edta lavage on success rates and postoperative pain in direct pulp capping of cariously exposed permanent teeth: a randomised controlled trial : Corresponding author.

Anshu Singh, Shweta Mittal, Sanjay Tewari, Jigyasa Duhan, Pankaj Sangwan, Vinay Kumar, Mayank Arora

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05878249 (Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05878249 naunknown statusnot on this map

Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure: A Randomized Controlled Trial

TypeinterventionalSponsorPostgraduate Institute of Dental Sciences RohtakRan2022 to 2024Enrolled140ConditionsReversible PulpitisArmswound lavage with normal saline, wound lavage with sodium hypochlorite, wound lavage with Ethylenediaminetetraacetic acid(EDTA), wound lavage with sodium hypochlorite followed by Ethylenediaminetetraacetic acid
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Anshu SinghDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.
Shweta MittalDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India. shwetagoelendo@gmail.com.
Sanjay TewariDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.
Jigyasa DuhanDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.
Pankaj SangwanDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.
Vinay KumarDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.
Mayank AroraDepartment of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to explore the effect of lavage with sterile saline (SS), sodium hypochlorite (NaOCl), and Ethylenediaminetetraacetic acid (EDTA) on success rate and postoperative pain in direct pulp capping of mature permanent teeth.

methodsIn this double-blind trial (NCT05878249), 140 patients with reversible pulpitis in permanent molars due to caries were enrolled. Following complete caries removal, hemostasis was achieved, and the cavities were randomly assigned to four groups for lavage: (European Society of Endodontology (ESE) developed by:, Duncan HF et al. Int Endod J 52(7):923-34, 2019); SS ( Asgary S et al. J Endod 44(4):529-35, 2018); 2.5% NaOCl ( Cushley S et al. Int Endod J 54(4):556-71, 2021); 12% EDTA, and ( Ricucci D et al. J Endod 49(1):45-54, 2023), 2.5% NaOCl followed by 12% EDTA (NaOCl/EDTA). Biodentine was applied to the exposed pulp, followed by a resin-modified glass-ionomer liner and composite restoration. Clinical and radiographic success was evaluated at 6 and 12 months. Visual Analog Scale was used to record pain for 7 days. Statistical analysis included Mann-Whitney U, Kruskal-Wallis, Chi-square tests, and Kaplan-Meier analysis. Multivariate Cox regression analysis was used to identify risk factors associated with tooth survival.

resultsThe overall clinical and radiographic success rate at 12 months was 86.9%. Individual success rates among groups were 71.9% (SS), 90.6% (NaOCl), 87.9% (EDTA), and 97.0% (NaOCl/EDTA). NaOCl/EDTA group showed significantly higher success rates than SS group (p < 0.05). NaOCl and NaOCl/EDTA groups showed a significant reduction in pain compared to SS group on days 5-7 (p < 0.05). Pulp survival analysis revealed an overall success rate of 87.9%. Survival rates among the groups were: SS group - 74.3%, NaOCl group - 91.4%, EDTA group - 88.6%, and NaOCl/EDTA group - 97.1%. Log-rank test revealed a significant difference in the survival between the groups (p = 0.020). NaOCl, EDTA, and NaOCl/EDTA provided higher survival probability (meaning fewer failures) compared to the use of SS alone (P > 0.05). The failure risk was 14.3 times higher with SS than with NaOCl/EDTA (HR: 14.3, 95% CI: 1.7-118.6, p = 0.013).

conclusionsThe combined use of NaOCl/EDTA increased the success rates at 12 months. NaOCl and NaOCl/EDTA elicited significantly less postoperative pain than other groups. CLINICAL RELEVANCE: Lavage with NaOCl/EDTA increased the success rates of direct pulp capping.

Indexed as

Dental CariesDental Pulp CappingEdetic AcidPostoperative PainPulpitisSodium HypochloriteAdultDentition, PermanentDouble-Blind MethodFemaleHumansMaleTherapeutic IrrigationTreatment OutcomeEdetic AcidSodium HypochloriteDirect pulp cappingEDTALavageSodium hypochloriteSterile saline

Identifiers

PMID41417101

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.