ArticleCancer chemotherapy and pharmacology2025
Pharmacokinetic comparison of cisplatin administration via HIPEC and intravenous infusion in a porcine model.
Article in Cancer chemotherapy and pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEpithelial ovarian cancer (EOC) is associated with high recurrence and poor prognosis. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) offers a locoregional treatment strategy. However, the pharmacokinetics of cisplatin administered via HIPEC compared to intravenous (IV) infusion remain insufficiently characterized. This study aimed to compare local abdominal tissue concentrations and systemic exposure of cisplatin following HIPEC and IV administration in a healthy porcine model using microdialysis.
methodsSixteen healthy Danish Landrace pigs were divided into HIPEC (n = 8) and IV (n = 8) groups. The HIPEC group underwent CRS followed by 90-minute cisplatin-based HIPEC. The IV group received an equivalent cisplatin dose intravenously (100 mg/m²). Microdialysis catheters were placed in the liver, rectum, stomach (superficial and profound layers) and peritoneum. Free cisplatin concentrations were quantified using UPLC-MS/MS.
resultsWithin the HIPEC group, cisplatin C
conclusionHIPEC concentrates cisplatin within the peritoneum while minimizing systemic distribution, whereas IV administration leads to a broad systemic and less targeted exposure. These findings support the pharmacologic rationale for HIPEC in maximizing local cytotoxicity and minimizing systemic toxicity in EOC treatment.
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