ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2025
Integrated multi-omics elucidates StAN1 as a key regulator reprogramming flavonoid partitioning and co-regulatory networks in potato tubers.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The R2R3-MYB transcription factor StAN1, a crucial regulator of anthocyanin biosynthesis in potato tubers, exerts previously unexplored global control over flavonoid diversification. Integrated transcriptomics (RNA-seq) and flavonoid metabolomics (UPLC-MS/MS) of StAN1-overexpressing tubers revealed its dual role in metabolic reprogramming: among 186 identified flavonoids, 122 exhibited tissue-specific accumulation shifts, with anthocyanins (e.g., pelargonidin/cyanidin), flavanones, and flavanonols upregulated in red flesh while flavonols (kaempferol/quercetin derivatives) were suppressed. Transcriptomic analyses identified 4783 flesh-specific and 2935 skin-specific differentially expressed genes (DEGs), pinpointing key biosynthetic genes and novel co-regulators (ERF, WRKY, bHLH TFs). Mechanistically, DAP-seq demonstrated StAN1 binding to promoters of flavonoid genes (e.g., StDFR), and dual-luciferase assays confirmed its direct activation of StDFR expression. Regulatory network expansion was evidenced by co-upregulation of RLKs (e.g., LRK10-like kinases), implicating kinase signaling in flavonoid partitioning. This study elucidates StAN1's multifaceted role beyond anthocyanin activation-orchestrating metabolic flux, engaging novel TF/kinase networks, and directly targeting structural genes-providing a foundation for engineering potatoes with enhanced nutraceutical properties via targeted manipulation of the StAN1 regulatory network.
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