ArticleAbdominal radiology (New York)2026
Construction of a predictive model for radiation proctitis after radical radiotherapy for cervical cancer based on MRI radiomics.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Mechanistic pathways predictive modeling and translational interventions for radiation enteritis in cervical cancer radiotherapy.Frontiers in cellular and infection microbiology · 2025Review
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9 authors.
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Abstract
purposeRadiation proctitis (RP) is a frequent and clinically relevant complication of radiotherapy (RT) in cervical cancer (CC). However, effective tools for individualized RP risk prediction remain limited. This study aimed to develop and validate an MRI-based radiomic risk score for early RP prediction in CC patients.
methodsThis retrospective study included 375 CC patients who underwent radical RT. Patients were randomly assigned to training (80%) and validation (20%) cohorts. Radiomics features were extracted from pre-treatment MRI and screened using Mann-Whitney U test, intraclass correlation coefficient, and least absolute shrinkage and selection operator regression. Logistic regression analyses identified independent predictors of RP, and a clinical-radiomics nomogram was constructed. Model performance was assessed by the area under the curve (AUC), calibration, and decision curve analysis (DCA).
resultsOf 1,906 extracted features, 9 were selected to construct the radiomics risk score. Independent predictors of RP included lymphocyte counts ≥ 2.6 × 10⁹/L, platelet-lymphocyte ratio ≥ 196, rectal mean dose ≥ 47.22 Gy, and radiomics risk score≥-0.4. The nomogram incorporating these factors achieved AUCs of 0.810 (training) and 0.730 (validation), with good calibration and clinical utility demonstrated by DCA.
conclusionThe proposed MRI-based radiomic risk score enables accurate, noninvasive prediction of RP in CC patients and provides a practical tool to optimize individualized RT planning and toxicity management.
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