ArticleEuropean journal of applied physiology2026
Influence of hydrostatic gradients and diurnal rhythm on cerebral and ocular blood flow.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vascular dynamics in the eyes and brain under microgravity have gained attention due to the Spaceflight-Associated Neuro-Ocular Syndrome (SANS). We explored how changes in gravitational vectors, circadian rhythm, and sleep regulate cerebral blood flow (CBF) and eye perfusion. Hypothesizing that the eye lacks the capacity to autoregulate, we expected increases in blood flow or volume to drive choroidal engorgement in SANS, and circadian and sleep-related changes to further influence these dynamics. Lower-body negative pressure (LBNP) was investigated as a countermeasure for posterior ciliary artery velocity (PCAv) changes. 16 participants were examined in seated, supine, lateral, and prone positions to assess blood flow in the internal carotid and vertebral artery, and PCAv and middle cerebral artery velocity (MCAv) via ultrasonography. CBF and PCAv were stable in-between horizontal positions, and both lowest in a seated position: CBF (supine, 1036 ± 231 vs. seated, 889 ± 177 ml∙min
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