Evidence map›Paper›PMID 41417060›Full record

ReviewEuropean journal of applied physiology2026

Advances in breath-hold diving research: a state-of-the-art review.

Matteo Paganini, Richard E Moon, Enrico M Camporesi, Gerardo Bosco

Abstract readReview
In one paragraph

Review in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matteo PaganiniDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padova, PD, Italy. matteo.paganini@unipd.it.ORCID http://orcid.org/0000-0002-7556-6928
Richard E MoonCenter for Hyperbaric Medicine and Environmental Physiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Enrico M CamporesiTEAMHealth Research Institute, Tampa General Hospital, Tampa, FL, USA.
Gerardo BoscoDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padova, PD, Italy. gerardo.bosco@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreath-hold diving (BHD, also referred to as freediving) represents an extreme physiological challenge, requiring adaptations to rapid changes in blood gas levels and hydrostatic pressure. Despite advances in understanding human responses to BHD, knowledge gaps remain. With this state-of-the-art review, research trends and progression were tracked to inform future investigation directions.

methodsA structured literature search was conducted in PubMed and Scopus (2005–2025), selecting peer-reviewed studies on physiological, biochemical, and biomechanical aspects of BHD. Thematic analysis identified eight major research areas: cardiovascular, pulmonary, and neurological systems, decompression stress, skeletal muscle and metabolism, training, long-term adaptations, and technological advancements.

resultsCardiovascular adaptations involve autonomic regulation, bradycardia, and splenic contraction, but uncertainties remain regarding individual variability. Pulmonary responses include lung compression, gas exchange inefficiencies, and potential risks of lung barotrauma. Neurological effects include hypoxia-induced syncope, cerebral blood flow changes, and emerging evidence of neurovascular damage. Decompression stress, once considered negligible, is now recognized in elite and repetitive divers. Training enhances apnea performance through hematological and metabolic adaptations, though long-term effects are unclear. Telemonitoring advancements are promising for future improvement of divers’ safety.

conclusionsRecent observations emphasize both adaptive and maladaptive aspects of BHD physiology. The synthesized research trends should aim at refining current achievements and identify what individual and environmental factors pose specific limits for human breath-hold performance underwater.

Indexed as

Breath HoldingDivingAdaptation, PhysiologicalDiving and Hyperbaric MedicineHumansApneaBreath-hold divingCardiovascular adaptationsDecompression stressDiving physiologyEnvironmental physiologyUnderwater

Identifiers

PMID41417060
PMCPMC13013280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.