Evidence map›Paper›PMID 41417052›Full record

ReviewPediatric nephrology (Berlin, Germany)2026

Precision approaches to paediatric hypertension: linking pathophysiology to therapy.

Emily Haseler, Manish D Sinha

Abstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emily HaselerDepartment of Paediatric Nephrology, Evelina London Children's Hospital, Guys & St Thomas NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.
Manish D SinhaDepartment of Paediatric Nephrology, Evelina London Children's Hospital, Guys & St Thomas NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK. manish.2.sinha@kcl.ac.uk.ORCID http://orcid.org/0000-0001-7593-1203

Funding

Medical Research Council MR/X001768/1
6 · The paper itself

Abstract

Blood pressure is the product of a complex interplay between the pumping action of the heart and the resistance capacity of both large and small arteries. These are modulated by several physiological processes, including the autonomic nervous system, renin angiotensin aldosterone system, neurohormonal influences and fluid balance. Dysregulation of one or more of these can lead to hypertension. Consideration of the key concepts underlying the generation and regulation of blood pressure is important to consider when selecting an appropriate antihypertensive agent. This review will outline the main physiological processes contributing to blood pressure and discuss their relevance to the pathophysiology and treatment of primary hypertension in children and young people.

Indexed as

Antihypertensive AgentsBlood PressureHypertensionPrecision MedicineAdolescentAutonomic Nervous SystemChildHumansRenin-Angiotensin SystemAntihypertensive AgentsAntihypertensive treatmentCardiovascular riskChildren and young peopleHaemodynamicsHypertensionObesityPersonalised medicine

Identifiers

PMID41417052
PMCPMC13337797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.