ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2025
Mandibular advancement devices in obstructive sleep apnea: diagnostic predictors for treatment response and clinical implications : A retrospective pilot cohort study.
Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesMandibular advancement devices (MADs) represent an established second-line therapy for obstructive sleep apnea (OSA), but therapeutic responses vary considerably. The primary aim of this retrospective pilot cohort study was to evaluate craniofacial characteristics, particularly the ANB angle, as potential diagnostic predictors of treatment response.
methodsAnamnestic, clinical, and poly(somno)graphic data were collected from OSA patients before MAD insertion (t0) and after final titration with poly(somno)graphic confirmation (t1). Cephalometric measurements, including hyoid bone position, were analyzed. Patients were stratified based on the ANB angle (ANB ≤ 4°: group 1; ANB > 4°: group 2). Statistical analysis included independent t‑tests, Pearson correlations, receiver operating characteristic (ROC) curve analysis, and multiple regression models to identify predictors of treatment response.
resultsA total of 38 patients (mean age 57.6 ± 11.7 years; 52% male) were included. Group 2 showed significantly greater reductions in Apnea-Hypopnea Index (AHI) at t1 (-84.6% vs. -39.8%, p < 0.001). ROC analysis identified an optimal ANB cut-off of 4.7° (AUC = 0.791), with 75% sensitivity and 81.2% specificity. In addition to ANB, higher Wits values and a smaller Björk polygon sum (hypodivergent pattern) independently predicted greater AHI reduction. Reductions in AHI were significantly correlated with improvements in Epworth Sleepiness Scale (ESS) scores.
conclusionCephalometric parameters predict a favorable response to MAD therapy for OSA. Integrating cephalometric analysis into the diagnostic workflow may improve patient selection and prognosis.
Indexed as
Identifiers
41417045What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.