Evidence map›Paper›PMID 41416941›Full record

ArticleEuropean journal of immunology2025

Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection.

Jaeyoon Song, Ricardo da Silva Antunes, Mehrnaz Agili Seyede, Monica Guma, Alessandro Sette, Alessandra Franco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jaeyoon SongSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Ricardo da Silva AntunesCenter For Vaccine Innovation, La Jolla Institute for Immunology (LJI); Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego (UCSD), La Jolla, California, USA.
Mehrnaz Agili SeyedeDepartment of Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA.
Monica GumaDepartment of Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA.
Alessandro SetteCenter For Vaccine Innovation, La Jolla Institute for Immunology (LJI); Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego (UCSD), La Jolla, California, USA.
Alessandra FrancoSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.

Funding

Gordon and Marylin Macklin FoundationNIH NIAID 75N9301900065Praespero, an Autoimmune Research Fund
6 · The paper itself

Abstract

The efficacy of mRNA-based vaccines to prevent COVID-19 in autoimmune patients is controversial due to immunosuppressive therapies. Here, we characterized the T cell responses to SARS-CoV-2 in rheumatoid arthritis (RA) subjects, who received as few as one or up to seven vaccine injections. The study population had different disease severities and an association with other autoimmune comorbidities. All the subjects studied showed SARS-CoV-2 spike-specific CD4+ T helper (Th) cells in circulation, and in most of the subjects, CD8

Indexed as

Arthritis, RheumatoidCOVID-19COVID-19 VaccinesSARS-CoV-2AdultAgedCD8-Positive T-LymphocytesFemaleHumansImmunologic MemoryMaleMiddle AgedSpike Glycoprotein, CoronavirusT-Lymphocytes, RegulatoryVaccinationCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2CD4−CD8− double negative (DN) T cellsregulatory T cellsSARS‐CoV‐2 vaccination in rheumatoid arthritisT cell memory

Identifiers

PMID41416941
PMCPMC12716210

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.