Evidence map›Paper›PMID 41416926›Full record

ArticleThe Journal of physiology2025

Amyloid β alters vascular Ca

Jade L Taylor, Miguel Martin-Aragon Baudel, Eric Pereira da Silva, Johannes W Hell, Madeline Nieves-Cintron, Manuel F Navedo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. CaThe Journal of physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jade L TaylorDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-7158-2712
Miguel Martin-Aragon BaudelDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-9399-4013
Eric Pereira da SilvaDepartment of Pharmacology, University of California Davis, Davis, CA, USA.
Johannes W HellDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-7960-7531
Madeline Nieves-CintronDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0003-1935-8400
Manuel F NavedoDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0001-6864-6594

Funding

Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Cerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7M
Postsynaptic Signaling by Norepinephrine and cAMPR01NS123050 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2022 to 2026
$2.3M
Mechanisms of VSM dysfunction in diabetes and HFpEFR01HL171014 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Manuel F Navedo, Madeline Nieves-Cintron · 2024 to 2026
$2.0M
Dysregulation of Cav1.2 by beta amyloid peptideRF1AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2022 to 2024
$1.7M
Pressure Regulation of Vascular CaV1.2 ChannelsR01HL180444 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Manuel F Navedo · 2025 to 2026
$1.5M
American Heart Association 1022782NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01HL121059NHLBI NIH HHS R01 HL149127NHLBI NIH HHS R01HL149127NHLBI NIH HHS R01 HL171014NHLBI NIH HHS R01HL171014NHLBI NIH HHS R01 HL180444NHLBI NIH HHS R01HL180444NIA NIH HHS RF1 AG055357NIA NIH HHS RF1AG055357NINDS NIH HHS R01 NS123050NINDS NIH HHS R01NS123050
6 · The paper itself

Abstract

A hallmark of Alzheimer's disease is reduced cerebral blood flow, which appears to occur early in disease progression and has been associated with amyloid β (Aβ) accumulation. Cerebral artery diameter is regulated by calcium influx via voltage-gated L-type Ca

Indexed as

Alzheimer's diseasecalciumcerebrovascular pathologysex dimorphism

Identifiers

PMID41416926
PMCPMC12857231

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.