ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundRed meat consumption is a risk factor for colorectal cancer and has been linked to tumor alkylating DNA damage. rs16906252-T is a cis expression quantitative trait locus variant associated with silencing of MGMT, a central alkylating damage repair gene. We hypothesize that rs16906252-T carriers are predisposed to alkylating damage mutations.
methodsWe conducted mutational signature deconvolution of colorectal cancer whole-exome sequencing data from The Cancer Genome Atlas (n = 540), the Nurses' Health Study / Health Professionals Follow-Up Study (NHS/HPFS, n = 900), as well as non-Western samples from the Pan-Cancer Analysis of Whole Genomes (Colorectal Adenocarcinoma in China cohort, n = 295) and examined the relationship of rs16906252-T with putative alkylation-dependent tumor mutations. Leveraging lifestyle data from the NHS/HPFS, we also investigated the interaction between red meat consumption and rs16906252-T.
resultsAmong patients with colorectal cancer, rs16906252-T carriers exhibited higher tumor alkylating damage compared with noncarriers. In the general population, rs16906252-T is largely absent in individuals with East Asian ancestries, and we consistently find a negligible contribution of alkylating damage in patients with colorectal cancer with East Asian ancestries. We show that the alkylating mutational signature's carcinogenicity is mainly mediated by KRAS G12D and G13D mutations. We also observe a synergistic effect of rs16906252-T with high prediagnosis red meat intake for tumor alkylating damage.
conclusionsMGMT rs16906252-T carriers are predisposed to colorectal cancer oncogenic alkylating damage which is potentiated by red meat intake. IMPACT: Our results support a causal relationship between red meat and colorectal cancer and may inform tailored dietary and screening guidelines for colorectal cancer prevention.
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