ArticleInternational forum of allergy & rhinology2026
Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells.
Joel C Thompson, April Park, Yobouet Ines Kouakou, Zoey A Miller, Nabil F Darwich, Nithin D Adappa, James N Palmer, Ryan M Carey, Robert J Lee
Abstract read
In one paragraphArticle in International forum of allergy & rhinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Joel C ThompsonDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Yobouet Ines KouakouDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Zoey A MillerDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Nabil F DarwichDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Nithin D AdappaDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
James N PalmerDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ryan M CareyDepartment of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Funding
Immune function of bitter taste receptors in human macrophagesR01AI167971 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Nithin Adappa, Robert J. Lee · 2022 to 2026
$2.5MIntracellular signaling in airway solitary chemosensory (tuft) cellsR01HL168060 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Robert J. Lee · 2024 to 2026
$1.4MSweet receptor T1R3 in airway glucose homeostasis and chronic rhinosinusitisR01HL181155 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Nithin Adappa, Robert J. Lee · 2025 to 2026
$1.0MAmerican Academy of Otolaryngology-Head and Neck Surgery AAO-HNSF Resident Research AwardCystic Fibrosis Foundation LEE25G0National Institute of Allergy and Infectious Diseases AI167971NHLBI NIH HHS HL168060NHLBI NIH HHS HL181155NHLBI NIH HHS R01 HL168060NHLBI NIH HHS R01 HL181155NIAID NIH HHS R01 AI167971
6 · The paper itselfAbstract
backgroundPseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis-related chronic rhinosinusitis (CF-CRS) that produces phenazine metabolites pyocyanin and 1-hydroxyphenazine (1-HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca
methodsLive cell imaging was used to measure Ca
resultsPyocyanin, but not 1-HP, increased mitochondrial Ca
conclusionsCa
Indexed as
Epithelial CellsMitochondriaNasal MucosaPseudomonas aeruginosaPseudomonas InfectionsPyocyanineCalciumCalcium SignalingCell Line, TumorCells, CulturedHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesCalciumPyocyanineReactive Oxygen Speciescalciumchronic rhinosinusitiscystic fibrosisgram‐negative bacteriahost–pathogen interactionslive cell imaging
Identifiers
PMID41416815
PMCPMC13147224
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