ArticleInvestigative radiology2025
Ready for Routine: Homogeneous, High-Resolution, and Multicontrast Whole-Brain MRI at 7 Tesla in Short Scan Time With "plug-and-Play" pTx Sequences.
Article in Investigative radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.Magnetic resonance in medicine · 2026Article
- Prospective Head Motion Correction in T1- and T2-Weighted Long Echo Train Sequences Using Servo Navigation.Magnetic resonance in medicine · 2026Article
- Magnetic resonance imaging.Science advances · 2026Review
- Clinical feasibility of contrast-enhanced 7 T MPRAGE with universal pulses for intracranial tumor imaging: a preliminary study.Neuroradiology · 2026Article
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Authors and funding
24 authors.
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Abstract
background7T MRI received FDA/CE clearance almost 7 years ago. However, until today, it has not yet been widely adopted in clinical routine. This is mainly due to field inhomogeneities that impede whole-brain coverage. Moreover, the long scan times often associated with high-resolution imaging are an additional limiting factor. PURPOSE: To combine calibration-free parallel transmit technology (pTx) using universal pulses (UP) with advanced imaging acceleration strategies to achieve homogenous multicontrast 7T MRI with whole-brain coverage and high spatial resolution in short scan time. MATERIALS AND
methodsTen healthy volunteers were scanned both with conventional vendor-provided sequences and with custom sequences for anatomical whole-brain imaging [-weighted, -weighted, FLAIR, and susceptibility-weighted]. The scan times for the 2 anatomical protocols were matched (25 minutes). In addition, a quantitative MRI protocol [multi-parametric mapping (MPM) and chemical exchange saturation transfer (CEST)] was scanned twice using custom sequences with conventional (circular polarized) and UPs, respectively, in a scan time of 2×25 minutes. Moreover, 4 patients with different neurological diseases were scanned, namely temporal lobe epilepsy, spinocerebellar ataxia, cerebral amyloid angiopathy, and glioblastoma. For the patients, only optimized custom sequences with UPs were acquired.
resultsCompared with conventional implementations, the custom sequences provide strongly improved image homogeneity and quality with significantly higher SNR and CNR across the whole brain, including cerebellum and brain stem. Moreover, UPs improve the repeatability of derived quantitative parameters. The suggested protocol has additionally been successfully demonstrated in 4 patients with different neurological pathologies.
conclusionsHomogeneous whole-brain 7T MRI with high spatial resolution and high image quality is possible in clinically feasible scan times. The developed protocol can be applied without any expert knowledge and is ready for clinical use. The approach could largely extend applicability of UHF MRI in neuroradiology paving the way for increased routine use of 7T MRI.
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