SynthesisCNS neuroscience & therapeutics2025
Glymphatic Pathway Dysfunction in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis Using Diffusion Tensor Imaging Along the Perivascular Space.
Synthesis in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Glymphatic Pathway Dysfunction in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis Using Diffusion Tensor Imaging Along the Perivascular Space.CNS neuroscience & therapeutics · 2025Pooled it
- The meningeal lymphatic vessel-peripheral immune axis: a novel therapeutic target in neurodegenerative diseases.Journal of neuroinflammation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate glymphatic dysfunction in mild cognitive impairment (MCI) using the diffusion tensor imaging along the perivascular space (DTI-ALPS) index.
methodsUsing PRISMA 2020, we searched PubMed, Web of Science, Scopus, and Embase (until May 10, 2025) for studies comparing the ALPS index in MCI patients versus healthy controls.
resultsThe pooled meta-analysis of 18 studies (1133 MCI patients, mean age 69.3 years; 1275 HCs) revealed a significantly lower ALPS index in MCI patients than in HCs (Cohen's d = -0.70; 95% CI: -1.10, -0.29; p < 0.001), with high heterogeneity (I
conclusionsThese findings support the utility of the ALPS index as a noninvasive biomarker for early glymphatic dysfunction in cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.