ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionDisruption of the autophagy-lysosomal pathway (ALP) compromises proteostasis and contributes to aging-related proteinopathy. Many studies indicate that a healthy diet can improve cognitive health and reduce the risk of Alzheimer-type pathogenesis.
methodsPlant-based products were tested in hippocampal explants for amplifying the ALP component cathepsin B (CatB), a protease reported to reduce proteinopathy and synaptopathy. Proof-of-concept experiments also tested Panax quinquefolius extract (PanQ) for improving cognitive function in aging rats.
resultsAmong the natural extracts tested, PanQ emerged as the most effective for increasing the active CatB isoform in correspondence with enhanced levels of synaptic proteins and the autophagy marker LC3-II. PanQ also increased synaptic resilience in a model of lysosomal stress and improved cognitive performance in 20-month-old rats. DISCUSSION: PanQ-mediated ALP enhancement implicates the proteostasis network in synaptic and cognitive maintenance mechanisms. This study also points to synaptic resiliency as an important factor underlying the influence of dietary components on cognitive health. HIGHLIGHTS: Panax quinquefolius (PanQ) enhanced cathepsin B (CatB) in hippocampal explants. The CatB modulation corresponded with enhanced synaptic and autophagy markers. PanQ improved synaptic resilience in the chloroquine (Cqn) model of lysosomal stress. Age-related cognitive deficit was reduced by PanQ supplementation in Fischer rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.