Evidence map›Paper›PMID 41416567›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2026

Wrinkling-Based Patterning and Recombinant Spider Silk-Based Coating Technologies - Toward Novel Applications.

Martin Humenik, Ziwei Zhou, Fabian Kopsch, Andre Knapp, Ziwen Yu, Hendrik Schlicke, Thomas Scheibel, Andreas Fery

Abstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin HumenikDepartment of Biomaterials, University of Bayreuth, Prof.-Rüdiger-Bormann-Str. 1, 95447, Bayreuth, Germany.
Ziwei ZhouLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.
Fabian KopschLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.
Andre KnappLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.
Ziwen YuLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.
Hendrik SchlickeLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.
Thomas ScheibelDepartment of Biomaterials, University of Bayreuth, Prof.-Rüdiger-Bormann-Str. 1, 95447, Bayreuth, Germany.ORCID https://orcid.org/0000-0002-0457-2423
Andreas FeryLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069, Dresden, Germany.

Funding

Deutsche Forschungsgemeinschaft 326998133(TRR225; subprojects A08 and C01)DFG CRC 1415 417590517DFG RTG 2767 451785257EU Interreg project BYCZ029 AIICHorizon 2020Leibniz Research Association "Advanced Materials Safety"
6 · The paper itself

Abstract

Wrinkling, formed by stress-induced energy minimization in thin polymer films, provides a reproducible method for large-area surface patterning. The resulting nano/micro topographies allow controlled spatial organization of nanomaterials for applications in sensing, optoelectronics, photocatalysis, and soft nanofabrication. The anisotropy of these wrinkled patterns can also be tuned for anti-biofouling or directional templating of biomolecules, which is crucial for hybrid bio-interfaces. Complementing this, spider silk-based surface technologies offer a flexible platform for creating biocompatible and biodegradable coatings. Recombinant spider silk protein technologies enable the modification of intrinsic protein properties (e.g., net charge) or incorporation of new functional elements (e.g., affinity peptides, enzymes). Spider silk-based coatings have been engineered for antifouling activities or to support cell adhesion and growth. In terms of biomedical applications, enhanced implant performance is feasible as well as tailored tissue engineering approaches. The synergistic combination of wrinkling and recombinant spider silk technology presents exciting opportunities for creation of surfaces with enhanced or new functionalities. For instance, spider silk wrinkled coatings can provide benefit for bioelectronics by encapsulating sensitive biomolecules within a topographically defined matrix, increasing sensitivity and specificity. This approach also offers innovations in biomedical device coatings, tissue engineering platforms (e.g., for neuronal or muscle tissue), large-scale bio-selective filtration, and switchable sustainable adhesives.

Indexed as

Coated Materials, BiocompatibleRecombinant ProteinsSilkSpidersAnimalsSurface PropertiesTissue EngineeringCoated Materials, BiocompatibleRecombinant ProteinsSilkanisotropyantifoulingbioelectronicsbiointerfacessurface engineering

Identifiers

PMID41416567
PMCPMC12802535

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.