Evidence map›Paper›PMID 41416445›Full record

ArticleMolecular medicine reports2026

ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis.

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yin TianDepartment of Gastroenterology, The People's Hospital of Yubei District of Chongqing City, Chongqing 401120, P.R. China.
Yun LiuInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.
Yangyang ShangInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.
Lijian RanInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.
Li LiuInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.
Rongquan WangInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.
Jun YeInstitute of Gastroenterology of People's Liberation Army, Southwest Hospital, Army Medical University, Chongqing 400038, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of inflammatory bowel disease is associated with dysfunction of the intestinal mucosal barrier. Protein sialylation serves an important role in maintaining the integrity of this barrier. The present study investigated how α2,3‑linked sialylation catalyzed by protein ST3Gal1 affected intestinal barrier function and impacted the pathogenesis of human ulcerative colitis (UC). The present study employed Caco‑2, HT29‑MTX‑E12 and THP‑1 cells with distinct functionalities to establish an

Indexed as

Colitis, UlcerativeIntestinal MucosaSialyltransferasesAdultAnimalsbeta-Galactoside alpha-2,3-SialyltransferaseCaco-2 CellsDextran SulfateDisease Models, AnimalFemaleHT29 CellsHumansIntestinal Barrier FunctionMaleMicePermeabilitybeta-Galactoside alpha-2,3-SialyltransferaseDextran SulfateSialyltransferasesbarrierinflammationsialylationST3Gal1triple culture model

Identifiers

PMID41416445
PMCPMC12750049

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.