ReviewInternational journal of oncology2026
CCDC137: A key hub for RNA and epigenetic regulation in cancer research (Review).
Review in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
The present study focused on the role of coiled‑coil domain‑containing protein 137 (CCDC137), an RNA‑binding and epigenetic protein with high expression and poor prognosis in various types of cancer. Bioinformatics analysis, cellular experiments and animal models investigated the functions of CCDC137 in RNA post‑transcriptional regulation, epigenetic modification and the tumor microenvironment. The results showed that CCDC137 can bind specific mRNAs to affect physiological processes such as the cell cycle, participate in epigenetic regulation such as DNA methylation and histone modification and influence tumor immune escape by affecting the functions of tumor‑associated macrophages. Based on the multidimensional regulatory functions of CCDC137, it is expected to become a new target for cancer diagnosis and treatment and provide a theoretical basis for precision cancer therapy.
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