Evidence map›Paper›PMID 41416403›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

A DNA methylation assay (MPap) using self-collected tampon versus cytology collection swab for endometrial cancer detection.

Kuo-Min Su, Kuo-Chang Wen, Yi-Hsin Lin, Po-Hsuan Su, Lin-Yu Chen, Hung Cheng Lai

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kuo-Min SuDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-7366-3671
Kuo-Chang WenDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yi-Hsin LinDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.ORCID https://orcid.org/0009-0002-9541-5403
Po-Hsuan SuCollege of Health Technology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1114-6382
Lin-Yu ChenDepartment of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0003-4870-3664
Hung Cheng LaiDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-8048-3943

Funding

National Defense Medical University MND-MAB-D-113071National Science and Technology Council MOST 110-2314-B-038-058National Science and Technology Council MOST 111-2314-B-038-110-MY2National Science and Technology Council NSTC 113-2314-B-016-001-MY2Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare 113TWS-W13Tri-Service General Hospital TSGH-D-114119Tri-Service General Hospital TSGH-E-113267
6 · The paper itself

Abstract

objectiveTo evaluate the practicability of self-collected tampons with the MPap assay for endometrial cancer (EC) detection, by comparing with the results of cervical swabs.

methodsA total of 85 women at Tri-Service General Hospital (TSGH) were included to directly compare the performance of physician-collected swabs and self-collected tampons. An additional cohort of 39 self-collected tampons from patients at Shuang Ho Hospital (SHH) was included for further validation. The effects of age, body mass index (BMI), and BHLHE22 and CDO1 methylation levels on MPap test performance were analyzed across samples from patients with and without EC. The performance of the MPap test is presented as percentage of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC). The Pearson's correlation test was used to examine the association between swab and tampon in the MPap test.

resultsThe area under the curve (AUC) of MPap to detect EC in 85 swabs and tampons both were 0.94 (0.88-1.00). The sensitivity, specificity, PPV, NPV, and ACC of the two collection methods did not show significant differences. The testing results using a tampon were highly correlated with the results using a physician-collected swab (R

conclusionOur data inferred the potential of the MPap test in early detection of EC using vaginal secretion collected by an intravaginal self-collected tampon.

Indexed as

DNA MethylationEndometrial NeoplasmsMenstrual Hygiene ProductsSpecimen HandlingAdultAgedFemaleHumansMiddle AgedPredictive Value of TestsSensitivity and SpecificityVaginal SmearsDNA methylation biomarkerendometrial cancerMPap testprecancer screeningswabtampon

Identifiers

PMID41416403
PMCPMC13173634

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.