Evidence map›Paper›PMID 41416382›Full record

ArticleStroke2026

Progression of Neuroinflammation Is Associated With Clinical Prognosis of Patients Undergoing Intravenous Thrombolysis.

Yang Qu, Tian Zhou, Chao Li, Reziya Abuduxukuer, Hang Jin, Peng Zhang, Hui-Min Li, Li-Juan Wang, Li-Chong Yang, Shuang-Xu Tan and 20 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Yang Qu *Department of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.
Tian Zhou *Department of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0009-0004-9704-3740
Chao LiDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.
Reziya AbuduxukuerDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.
Hang JinDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0000-0003-0300-5918
Peng ZhangDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0000-0001-5536-0255
Hui-Min LiDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.
Li-Juan WangDepartment of Neurology, Songyuan Central Hospital, China (L.-J.W.).
Li-Chong YangDepartment of Neurology, Jilin Neuropsychiatric Hospital, Siping, China (L.-C.Y.).
Shuang-Xu TanDepartment of Neurology, Stroke Center, Siping Central People's Hospital, China (S.-X.T.).
Zhi-Mei YuanDepartment of Neurosurgery, Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital, China (Z.-M.Y.).
Ce HanDepartment of Neurology, Songyuan Jilin Oilfield Hospital, China (C.H.).
Li-Li HeDepartment of Neurology, Stroke Center, Dehuishi People's Hospital, Changchun, China (L.-L.H.).
Yu-Ping ZhengDepartment of Neurology, Affiliated Hospital of Jilin Medical College, China (Y.-P.Z., L.J.).
Feng-Lan ZhaoDepartment of Neurology, Songyuan Hospital of Integrated Traditional Chinese and Western Medicine, China (F.-L.Z.).
Li-Jie GuoDepartment of Neurology, Stroke Center, Qianguoerros Mongolian Autonomous County Hospital, Songyuan, China (L.-J.G.).
Ligang JiangDepartment of Neurology, Affiliated Hospital of Jilin Medical College, China (Y.-P.Z., L.J.).
Jin-Feng LiDepartment of Neurology, Jilin City Hospital of Chemical Industry, China (J.-F.L., H.X., X.-J.W.).
Yongfei JiangDepartment of Neurology, Changchun People's Hospital, China (Y.J.).
Xue-Xia ZouDepartment of Neurology, Dongliao First People's Hospital, Liaoyuan, China (X.-X.Z.).
Dan XuDepartment of Neurology, Jilin People's Hospital, China (D.X.).
Han XuDepartment of Neurology, Jilin City Hospital of Chemical Industry, China (J.-F.L., H.X., X.-J.W.).
Xiao-Jia WangDepartment of Neurology, Jilin City Hospital of Chemical Industry, China (J.-F.L., H.X., X.-J.W.).
Yingbin QiDepartment of Neurology, Jilin Province People's Hospital, Changchun, China (Y. Qi, Y.Z.).
Xue-Feng HuDepartment of Neurology, Stroke Center, Jilin Central General Hospital, China (X.-F.H.).
Yu ZhangDepartment of Neurology, Jilin Province People's Hospital, Changchun, China (Y. Qi, Y.Z.).
Xin SunDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0009-0008-7483-7766
Yi YangDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-9729-8522
Zhen-Ni GuoDepartment of Neurology, Stroke Center (Y. Qu, T.Z., C.L., R.A., H.J., P.Z., H.-M.L., X.S., Y.Y., Z.-N.G.), The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-8922-3862
Biomarkers of Brain Injury Investigator Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent research has shown that neuroinflammation progresses rapidly within a few hours after stroke; however, the relationship between its progression and clinical outcomes remains unclear. Therefore, this study aimed to investigate the effect of neuroinflammation, measured by serum GFAP (glial fibrillary acidic protein), on patient outcomes, as well as the influence of baseline peripheral inflammation on the progression of neuroinflammation.

methodsThis prospective cohort study enrolled patients with acute ischemic stroke who received intravenous thrombolysis (IVT) between September 2016 and April 2023 across 16 centers in China. Serum GFAP levels were measured before (baseline, within 4.5 hours of onset) and at 24 hours after IVT. GFAP changes were determined by subtracting baseline levels from those measured 24 hours post-IVT. Outcome measures included final infarct volume during hospitalization, National Institutes of Health Stroke Scale scores at 24 hours and 7 days post-IVT, early neurological deterioration within 24 hours, delayed neurological deterioration within 7 days, and 3-month modified Rankin Scale scores. A modified Rankin Scale score of ≥2 was classified as an unfavorable outcome. Peripheral inflammation indicators were measured at baseline. Binary logistic and linear regressions were used as the main statistical methods.

resultsOverall, 743 patients were included. A significant increase in GFAP levels was observed, indicating progression of neuroinflammation. Regression analyses revealed that increased GFAP after IVT was independently associated with larger infarct volume (β, 30.965 [95% CI, 19.185-42.745];

conclusionsThe increase in GFAP levels over the first 24 hours after IVT is independently associated with clinical outcomes, with higher baseline peripheral inflammation correlating with greater GFAP elevation during that period.

Indexed as

Fibrinolytic AgentsGlial Fibrillary Acidic ProteinIschemic StrokeNeuroinflammatory DiseasesThrombolytic TherapyAdministration, IntravenousAgedCohort StudiesDisease ProgressionFemaleHumansInflammationMaleMiddle AgedPrognosisProspective StudiesFibrinolytic AgentsGFAP protein, humanGlial Fibrillary Acidic Proteinglial fibrillary acidic proteininflammationneuroinflammatory diseasesprognosisthrombolytic therapy

Identifiers

PMID41416382
PMCPMC12928816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.