ReviewCureus2025
Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sinoatrial node (SAN) functions as the primary pacemaker of the heart, initiating rhythmic electrical impulses that govern cardiac contraction. It consists of specialised pacemaker cells located between the superior vena cava and the right atrium, supported by a paranodal region that contributes to rhythm stabilisation and may serve as a secondary pacemaker during dysfunction. This review describes the structural organisation and molecular regulation of the SAN, with particular focus on the role of HCN4 ion channels and the influence of the microRNA miR-486-3p in modulating pacemaker activity. Understanding this relationship may support the development of novel therapeutic strategies for managing conditions such as sinus tachycardia, offering potential alternatives to existing pharmacological approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.