ArticleCureus2025
Necrotizing Autoimmune Myopathy With HMGCR Antibodies: An Uncommon Presentation of Autoimmune Myositis in a Middle-Aged Woman Without Known Malignancy, Connective Tissue Disorder, or Statin Therapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Atopic dermatitis management: integrating disease mechanisms with precision medicine and nanotechnology-based targeted therapies.Irish journal of medical science · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
We report an uncommon presentation of necrotizing autoimmune myopathy (NAM) associated with anti-HMGCR antibodies in a middle-aged woman who lacked typical risk factors, including statin use, malignancy, or connective tissue disease. The patient presented with muscle weakness, markedly elevated creatine kinase levels, and muscle biopsy findings consistent with necrosis. Diagnosis of NAM was confirmed through the detection of anti-HMGCR antibodies. Despite the initiation of corticosteroid therapy, the condition progressed rapidly, highlighting the aggressive nature of this form of autoimmune myositis. This case underscores the importance of considering NAM in the differential diagnosis of idiopathic myopathy, even in the absence of common predisposing factors, and emphasizes the need for early detection and individualized treatment strategies.
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