ArticleCureus2025
Utility of the Apparent Diffusion Coefficient in the Differential Diagnosis of Oral Malignant Lymphoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
objectiveMalignant lymphoma (ML), a lymphocyte-derived malignancy, is classified into Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). In the oral cavity, NHL is the predominant type. However, diagnosing oral ML is challenging owing to its clinical similarity to other lesions. Diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient (ADC) values may aid in differential diagnosis. Therefore, in the present study, we aimed to evaluate the usefulness of ADC in distinguishing ML from squamous cell carcinoma (SCC) and salivary gland carcinoma (SGC).
methodsThis retrospective study included 11 patients with ML, 35 with SCC, and 19 with SGC treated at our institution between 2012 and 2022. Clinical data and ADC values were analyzed, and magnetic resonance imaging was performed using a 3.0 T scanner.
resultsClinical assessment alone frequently resulted in misclassification of ML cases, with most cases initially suspected of having benign or other malignant tumors. ML demonstrated markedly lower ADC values (mean 0.67 ± 0.13 × 10⁻
conclusionADC assessment may facilitate early suspicion of oral ML and help clinicians in prioritizing it within the differential diagnosis. Integrating ADC values into the diagnostic workflow could facilitate early recognition and more appropriate biopsy strategies, thus supporting timely management.
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