Evidence map›Paper›PMID 41416261›Full record

ArticleCureus2025

Progressive Cerebral Atrophy and Cognitive Decline Without Cerebral Lesion in Neuromyelitis Optica Spectrum Disorder: A Case Report.

Susumu Fujikawa, Fumitaka Shimizu, Masaya Honda, Michiaki Koga, Masayuki Nakamori

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susumu FujikawaDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.
Fumitaka ShimizuDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.
Masaya HondaDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.
Michiaki KogaDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.
Masayuki NakamoriDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological deficits in neuromyelitis optica spectrum disorder (NMOSD) are conventionally thought to result from acute relapses, unlike multiple sclerosis (MS), which frequently progresses without relapse due to neurodegeneration. However, we present the case of a 41-year-old male patient who showed progressive bilateral frontal lobe atrophy over nine years, although acute relapses were limited to the medulla and spinal cord. Neuropsychological testing indicated cognitive decline. This case demonstrates progressive cerebral atrophy and cognitive decline, independent of relapses in NMOSD, possibly suggesting subclinical dying-back degeneration.

Indexed as

cerebral atrophycognitive declinefrontal lobe atrophyneuromyelitis optica spectrum disordersilent progression

Identifiers

PMID41416261
PMCPMC12708970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.