ArticleClinical Medicine Insights. Oncology2025
Colonic Gastrointestinal Stromal Tumors Demonstrate Unique Biological Characteristics: A Retrospective, Propensity Score-Matched Cohort Study Pooling Multicenter and Literature-Derived Individual Patient Data.
Article in Clinical Medicine Insights. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Immunotherapy checkpoint inhibitor-combination therapy versus chemotherapy alone among Chinese population in cholangiocarcinoma treatment: a systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colonic gastrointestinal stromal tumors (cGISTs) represent an exceptionally rare subtype of gastrointestinal stromal tumors (GISTs) and exhibit distinct clinicopathological features. Nonetheless, limited research has systematically assessed the prognostic differences between cGISTs and GISTs originating from other anatomical sites under comparable baseline and oncological conditions. Current prognostic stratification systems for GISTs have significant limitations in evaluating colonic subtypes. Methods: A retrospective case-control study. Surgical cGIST cases (2012-2024) from 4 tertiary hospitals were analyzed, along with 676 contemporaneous gastric GISTs (gGISTs) controls. Additional individual patient data were extracted from published articles, reviews, letters, and comments identified through a systematic literature search. Propensity score matching (1:4) was performed to balance baseline variables before comparing survival outcomes. Results: Compared with gGISTs, cGISTs exhibited distinct clinicopathological characteristics, including older average age ( Conclusions: The cGISTs exhibit distinct clinicopathological characteristics and are associated with a significantly poorer prognosis compared with gGISTs. Therefore, diagnostic and therapeutic strategies for cGISTs warrant further exploration and refinement.
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