Evidence map›Paper›PMID 41416222›Full record

ArticlePNAS nexus2025

Mutation-specific roles of sustained sodium current (I

Vichaya Auvichayapat, Sarin Lekchuensakul, Pharawee Wandee, John Mauleekoonphairoj, Sirikorn Vongseenin, Praewphan Ingrungruanglert, Nipan Israsena, Phichaya Suthivanich, Damrongsak Jinarat, Apichai Khongphatthanayothin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vichaya AuvichayapatScience Program in Physiology, Graduate School, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0001-6750-034X
Sarin LekchuensakulCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0001-6601-5916
Pharawee WandeeCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0002-2676-0767
John MauleekoonphairojCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.
Sirikorn VongseeninDepartment of Physiology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0009-0009-2973-6816
Praewphan IngrungruanglertCenter of Excellence for Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0001-6820-4542
Nipan IsrasenaCenter of Excellence for Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0003-1954-6567
Phichaya SuthivanichScience Program in Physiology, Graduate School, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0009-0006-9424-3311
Damrongsak JinaratCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0009-0004-7203-5226
Apichai KhongphatthanayothinCenter of Excellence in Arrhythmia Research Chulalongkorn University, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0001-5738-1738
Saknan Bongsebandhu-PhubhakdiDepartment of Physiology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd., Pathum Wan, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0003-2357-3568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long QT syndrome type 3 (LQTS3), caused by gain-of-function mutations in the

Indexed as

antiarrhythmic drugsmolecular modelingpatch clamp recordingprecision medicinesustained sodium current

Identifiers

PMID41416222
PMCPMC12708342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.